Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2298 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2298 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0712 | 0.0712 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.4403 | 0.5381 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0712 | 0.0091 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2298 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0712 | 0.0091 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.2298 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0453 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.4688 | 0.6015 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.2298 | 0.2095 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.2298 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7362 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0712 | 0.3046 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2298 | 0.2298 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.4403 | 0.5396 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.2298 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Onchocerca volvulus | 0.0034 | 0.4403 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0453 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.2298 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2298 | 0.2298 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.2298 | 0.2453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.2298 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 0.2299 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0712 | 0.0091 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0712 | 0.0091 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7362 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0712 | 0.0712 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4403 | 0.4403 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0712 | 0.0712 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0712 | 0.0712 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.4688 | 0.4688 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.2298 | 0.2453 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.2298 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.2298 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2298 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2298 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0712 | 0.0712 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0712 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.4688 | 0.4688 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2298 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.2299 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.4688 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0712 | 0.0712 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.2298 | 0.2119 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.2298 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0712 | 0.0712 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0712 | 0.0712 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.2299 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0065 | 0.8869 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.2 mg kg-1 | Inhibition of passive cutaneous anaphylaxis (PCA) in Charles Rivers Sprague-Dawley rat after intravenous administration; value range from 0.8 to 1.6 | ChEMBL. | 6131133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.