Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.1019 | 0.4091 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0062 | 0.0151 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.1019 | 0.4091 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.1019 | 0.4091 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0062 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0062 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.0627 | 0.1402 |
Schistosoma mansoni | hypothetical protein | 0.1019 | 0.4091 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0062 | 0.0151 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0627 | 0.1402 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0062 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0627 | 0.1402 |
Mycobacterium ulcerans | hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0627 | 0.1402 |
Giardia lamblia | Transglutaminase/protease, putative | 0.1019 | 0.4091 | 0.5 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.1019 | 0.4091 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0059 | 0.9606 |
Mycobacterium tuberculosis | Long conserved protein | 0.1019 | 0.4091 | 0.5 |
Brugia malayi | Thioredoxin family protein | 0.1019 | 0.4091 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.1019 | 0.4091 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.004 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.