Detailed information for compound 1403367

Basic information

Technical information
  • TDR Targets ID: 1403367
  • Name: N-(2,4-dichlorophenyl)-4-pyrimidin-2-ylpipera zine-1-carboxamide
  • MW: 352.219 | Formula: C15H15Cl2N5O
  • H donors: 1 H acceptors: 3 LogP: 2.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)NC(=O)N1CCN(CC1)c1ncccn1
  • InChi: 1S/C15H15Cl2N5O/c16-11-2-3-13(12(17)10-11)20-15(23)22-8-6-21(7-9-22)14-18-4-1-5-19-14/h1-5,10H,6-9H2,(H,20,23)
  • InChiKey: DMONMWALVXNPEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,4-dichlorophenyl)-4-pyrimidin-2-yl-piperazine-1-carboxamide
  • N-(2,4-dichlorophenyl)-4-(2-pyrimidinyl)-1-piperazinecarboxamide
  • ZINC00816393
  • MLS000764823
  • SMR000290428
  • 4-Pyrimidin-2-yl-piperazine-1-carboxylic acid (2,4-dichloro-phenyl)-amide
  • BAS 09615830

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.011 0.011
Brugia malayi sulfakinin receptor protein 0.0039 0.011 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.011 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.011 0.011
Schistosoma mansoni myosin xvIII 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.011 0.011
Echinococcus granulosus neuropeptide s receptor 0.0039 0.011 0.011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.011 0.011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0052 0.1398
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Echinococcus granulosus neuropeptide receptor 0.0039 0.011 0.011
Echinococcus granulosus orexin receptor type 2 0.0039 0.011 0.011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0314 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0347 0.0347
Brugia malayi ORL1-like opioid receptor 0.0039 0.011 0.011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.011 0.011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.011 0.011
Brugia malayi Serotonin receptor 0.0039 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi RE15519p 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0039 0.011 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.011 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0079 0.0373 1
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.011 0.011
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Brugia malayi neuropeptide F receptor 0.0039 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0039 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.011 0.011
Echinococcus granulosus g protein coupled receptor 0.0039 0.011 0.011
Echinococcus granulosus sex peptide receptor 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.011 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.011 0.011
Echinococcus multilocularis serotonin receptor 0.0039 0.011 0.011
Echinococcus multilocularis serotonin receptor 0.0039 0.011 0.011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi Cytochrome P450 family protein 0.0079 0.0373 0.0373
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.011 0.011
Schistosoma mansoni adenoreceptor 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis orexin receptor type 2 0.0039 0.011 0.011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.011 0.011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.011 0.011
Brugia malayi Serotonin receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni amine GPCR 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi GnHR receptor homolog 0.0039 0.011 0.011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.011 0.011
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0052 0.1398
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Echinococcus granulosus somatostatin receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0314 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni amine GPCR 0.0039 0.011 0.011
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0392 0.0392
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.011 0.011
Brugia malayi follicle stimulating hormone receptor 0.0039 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0039 0.011 0.011
Brugia malayi larval opioid receptor 0.0039 0.011 0.011
Echinococcus granulosus serotonin receptor 0.0039 0.011 0.011
Brugia malayi Dopamine receptor protein 1 0.0039 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0039 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0039 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0039 0.011 0.011
Brugia malayi Cytochrome P450 family protein 0.0079 0.0373 0.0373
Brugia malayi putative neuropeptide receptor 0.0039 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.011 0.011
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.011 0.011
Echinococcus multilocularis allatostatin A receptor 0.0039 0.011 0.011
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni histamine h1 receptor 0.0039 0.011 0.011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.011 0.011
Leishmania major cytochrome p450-like protein 0.0079 0.0373 1
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.011 0.011
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.011 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.0373 0.0373
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.011 0.011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0052 0.1398
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.003 0.0052 0.0052
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.011 0.011
Loa Loa (eye worm) CYP4Cod1 0.0079 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.0373 0.0373
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine receptor 0.0039 0.011 0.011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.011 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0052 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0222 0.0222
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.011 0.011
Brugia malayi G-protein coupled receptor 0.0039 0.011 0.011
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.011 0.011
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.011 0.011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0347 0.0347
Echinococcus granulosus g protein coupled receptor 0.0039 0.011 0.011
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0052 1
Brugia malayi Dopamine receptor 0.0039 0.011 0.011
Brugia malayi neuropeptide F receptor 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide receptor 0.0039 0.011 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.011 0.011
Echinococcus granulosus allatostatin A receptor 0.0039 0.011 0.011
Echinococcus granulosus neuropeptide receptor 0.0039 0.011 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0052 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis fmrfamide receptor 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.011 0.011
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0052 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.011 0.011
Leishmania major hypothetical protein, conserved 0.003 0.0052 0.1398
Brugia malayi hypothetical protein 0.003 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.011 0.011
Giardia lamblia Ceramide glucosyltransferase 0.0691 0.4451 0.5
Echinococcus granulosus g-protein coupled receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi Melatonin receptor type 1A 0.0039 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0039 0.011 0.011
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus fmrfamide receptor 0.0039 0.011 0.011
Echinococcus granulosus hypothetical protein 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.011 0.011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.011 0.011
Trypanosoma brucei cytochrome P450, putative 0.0079 0.0373 1
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine receptor 0.0039 0.011 0.011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Brugia malayi G-protein coupled receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine receptor 0.0039 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.011 0.011
Schistosoma mansoni opsin-like receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.011 0.011
Echinococcus multilocularis fmrfamide receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus g protein coupled receptor 0.0039 0.011 0.011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.011 0.011
Schistosoma mansoni amine GPCR 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi G protein-coupled receptor 0.0039 0.011 0.011
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.0039 0.011 0.011
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0392 0.0392
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.011 0.011
Echinococcus multilocularis somatostatin receptor 0.0039 0.011 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0079 0.0373 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.011 0.011
Brugia malayi AKH receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi hypothetical protein 0.0039 0.011 0.011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.011 0.011
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.011 0.011
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.011 0.011
Brugia malayi Dopamine receptor protein 2 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0347 0.0347
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.011 0.011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0079 0.0373 1
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.011 0.011
Schistosoma mansoni amine GPCR 0.0039 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.011 0.011
Schistosoma mansoni amine GPCR 0.0039 0.011 0.011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis neuropeptide receptor 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0281 0.0281
Echinococcus multilocularis sex peptide receptor 0.0039 0.011 0.011
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.011 0.011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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