Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0506 | 0.2876 | 0.4271 |
Schistosoma mansoni | carbonic anhydrase | 0.0506 | 0.2876 | 0.3014 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1552 | 0.9541 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1552 | 0.9541 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0506 | 0.2876 | 0.3014 |
Schistosoma mansoni | hypothetical protein | 0.0506 | 0.2876 | 0.3014 |
Echinococcus multilocularis | carbonic anhydrase | 0.0506 | 0.2876 | 0.4271 |
Onchocerca volvulus | 0.0219 | 0.1043 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.2876 | 0.4157 |
Echinococcus granulosus | carbonic anhydrase | 0.0506 | 0.2876 | 0.4271 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.1431 | 0.2069 |
Echinococcus multilocularis | carbonic anhydrase | 0.0506 | 0.2876 | 0.4271 |
Loa Loa (eye worm) | hypothetical protein | 0.114 | 0.6917 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0506 | 0.2876 | 0.4271 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0506 | 0.2876 | 0.4157 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1111 | 0.6734 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0506 | 0.2876 | 0.4271 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0834 | 0.4965 | 0.7358 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1111 | 0.6734 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1111 | 0.6734 | 0.9734 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1111 | 0.6734 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1111 | 0.6734 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0506 | 0.2876 | 0.4271 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.1431 | 0.2125 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1111 | 0.6734 | 0.7057 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1552 | 0.9541 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1552 | 0.9541 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1111 | 0.6734 | 0.7057 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0506 | 0.2876 | 0.4271 |
Echinococcus granulosus | carbonic anhydrase II | 0.1111 | 0.6734 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0506 | 0.2876 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1043 | 0.6295 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0506 | 0.2876 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0506 | 0.2876 | 0.3014 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1111 | 0.6734 | 0.9734 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1111 | 0.6734 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0506 | 0.2876 | 0.4271 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1111 | 0.6734 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0506 | 0.2876 | 0.4271 |
Onchocerca volvulus | Putative sulfate transporter | 0.0219 | 0.1043 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0971 | 0.5837 | 0.9089 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.2876 | 0.4157 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0506 | 0.2876 | 0.3014 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0506 | 0.2876 | 0.4271 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.