Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.1457 | 0.9304 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1214 | 0.6796 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1457 | 0.9304 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0911 | 0.3677 | 0.6554 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1214 | 0.6796 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1214 | 0.6796 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1214 | 0.6796 | 0.7305 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1214 | 0.6796 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1214 | 0.6796 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1214 | 0.6796 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1214 | 0.6796 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1214 | 0.6796 | 0.7305 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0979 | 0.4374 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1214 | 0.6796 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1457 | 0.9304 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1214 | 0.6796 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1457 | 0.9304 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.