Detailed information for compound 1406596

Basic information

Technical information
  • TDR Targets ID: 1406596
  • Name: N-[(5-methylfuran-2-yl)methyl]-3-[1-(quinolin -8-ylmethyl)piperidin-3-yl]propanamide
  • MW: 391.506 | Formula: C24H29N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.37 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccc(o1)C)CCC1CCCN(C1)Cc1cccc2c1nccc2
  • InChi: 1S/C24H29N3O2/c1-18-9-11-22(29-18)15-26-23(28)12-10-19-5-4-14-27(16-19)17-21-7-2-6-20-8-3-13-25-24(20)21/h2-3,6-9,11,13,19H,4-5,10,12,14-17H2,1H3,(H,26,28)
  • InChiKey: IRUNKAFOIOTZLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(5-methyl-2-furyl)methyl]-3-[1-(8-quinolylmethyl)-3-piperidyl]propanamide
  • N-[(5-methyl-2-furyl)methyl]-3-[1-(8-quinolylmethyl)-3-piperidinyl]propanamide
  • N-[(5-methyl-2-furyl)methyl]-3-[1-(8-quinolylmethyl)-3-piperidyl]propionamide
  • MLS000733427
  • N-[(5-methyl-2-furyl)methyl]-3-[1-(quinolin-8-ylmethyl)piperidin-3-yl]propanamide
  • SMR000315366

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0109 0.0931 0.3156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0008 0.0027
Schistosoma mansoni myosin xvIII 0.0109 0.0931 0.3156
Echinococcus multilocularis orexin receptor type 2 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0931 0.3156
Schistosoma mansoni histamine h1 receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptide s receptor 0.0109 0.0931 0.3156
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0931 0.0924
Echinococcus multilocularis protein kinase c iota type 0.0034 0.0008 0.0027
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0008 0.0027
Echinococcus granulosus neuropeptide receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni neuropeptide receptor 0.0109 0.0931 0.3156
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Brugia malayi neuropeptide F receptor 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus 7TM GPCR rhodopsin 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis allatostatin A receptor 0.0109 0.0931 0.3156
Echinococcus granulosus alpha 1A adrenergic receptor 0.0109 0.0931 0.3156
Schistosoma mansoni atypical protein kinase C 0.0034 0.0008 0.0027
Brugia malayi p70 ribosomal S6 kinase beta 0.0066 0.0398 0.039
Schistosoma mansoni neuropeptide receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni amine GPCR 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0931 0.3156
Brugia malayi Protein kinase domain containing protein 0.0057 0.0298 0.029
Schistosoma mansoni opsin-like receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Echinococcus granulosus dro:myosuppressin receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus cGMP dependent protein kinase 1 0.0044 0.0137 0.0464
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus g protein coupled receptor 0.0109 0.0931 0.3156
Brugia malayi putative neuropeptide receptor 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni amine GPCR 0.0109 0.0931 0.3156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0931 0.3156
Toxoplasma gondii AGC kinase 0.0066 0.0398 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis protein kinase c epsilon type 0.0034 0.0008 0.0027
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0109 0.0931 0.0924
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Brugia malayi putative neuropeptide receptor NPR1 0.0109 0.0931 0.0924
Brugia malayi Melatonin receptor type 1A 0.0109 0.0931 0.0924
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0931 0.3156
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0109 0.0931 0.0924
Echinococcus granulosus protein kinase c iota type 0.0034 0.0008 0.0027
Schistosoma mansoni hypothetical protein 0.0109 0.0931 0.3156
Entamoeba histolytica protein kinase, putative 0.0034 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Echinococcus granulosus orexin receptor type 2 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Entamoeba histolytica protein kinase, putative 0.0066 0.0398 0.0798
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni hypothetical protein 0.0109 0.0931 0.3156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0109 0.0931 0.0924
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0398 0.039
Schistosoma mansoni neuropeptide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni adenoreceptor 0.0109 0.0931 0.3156
Echinococcus granulosus neuropeptide receptor A26 0.0109 0.0931 0.3156
Echinococcus granulosus NDR protein kinase 0.0034 0.0008 0.0027
Onchocerca volvulus 0.0271 0.2931 0.9905
Schistosoma mansoni serine/threonine kinase 0.0034 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus neuropeptide s receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis g-protein coupled receptor 0.0109 0.0931 0.3156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0931 0.3156
Echinococcus multilocularis somatostatin receptor 0.0109 0.0931 0.3156
Echinococcus granulosus g-protein coupled receptor 0.0109 0.0931 0.3156
Echinococcus granulosus fmrfamide receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0931 0.3156
Schistosoma mansoni amine GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0008 0.0027
Echinococcus granulosus peptide allatostatin:somatostatin 0.0109 0.0931 0.3156
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Echinococcus granulosus sex peptide receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0044 0.0137 0.0464
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0931 0.0924
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0109 0.0931 0.0924
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Echinococcus granulosus cGMP dependent protein kinase 0.0044 0.0137 0.0464
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0931 0.3156
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0057 0.0298 0.029
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0931 0.3156
Brugia malayi AKH receptor 0.0109 0.0931 0.0924
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis G-protein coupled receptor, putative 0.0109 0.0931 0.3156
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Echinococcus granulosus serotonin receptor 0.0109 0.0931 0.3156
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0137 0.0464
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis dro:myosuppressin receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis sex peptide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0931 0.3156
Brugia malayi Serotonin receptor 0.0109 0.0931 0.0924
Echinococcus multilocularis expressed conserved protein 0.0044 0.0137 0.0464
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0931 0.3156
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0109 0.0931 0.3156
Brugia malayi G-protein coupled receptor 0.0109 0.0931 0.0924
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0931 0.3156
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0931 0.3156
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0931 0.0924
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Brugia malayi larval opioid receptor 0.0109 0.0931 0.0924
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0056 0.0279 0.695
Loa Loa (eye worm) TYRA-2 protein 0.0109 0.0931 0.0924
Echinococcus granulosus neuropeptide receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0109 0.0931 0.0924
Echinococcus granulosus hypothetical protein 0.0109 0.0931 0.3156
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis rho associated protein kinase 0.0273 0.295 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0931 0.3156
Entamoeba histolytica hypothetical protein 0.0438 0.498 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0931 0.3156
Echinococcus multilocularis G protein coupled receptor 139 0.0109 0.0931 0.3156
Brugia malayi follicle stimulating hormone receptor 0.0109 0.0931 0.0924
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni amine GPCR 0.0109 0.0931 0.3156
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0008 0.0027
Entamoeba histolytica protein kinase, putative 0.0066 0.0398 0.0798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Schistosoma mansoni biogenic amine receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0931 0.3156
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0008 0.0027
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0109 0.0931 0.3156
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni opsin-like receptor 0.0109 0.0931 0.3156
Schistosoma mansoni growth hormone secretagogue receptor 0.0109 0.0931 0.3156
Brugia malayi GnHR receptor homolog 0.0109 0.0931 0.0924
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0109 0.0931 0.3156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi sulfakinin receptor protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) AGC/PKG protein kinase 0.0044 0.0137 0.0129
Brugia malayi ORL1-like opioid receptor 0.0109 0.0931 0.0924
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis serine threonine protein kinase 0.0034 0.0008 0.0027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0109 0.0931 0.3156
Brugia malayi G protein-coupled receptor F59B2.13 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Schistosoma mansoni hypothetical protein 0.0109 0.0931 0.3156
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) melatonin receptor type 1A 0.0109 0.0931 0.0924
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni hypothetical protein 0.0109 0.0931 0.3156
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0298 0.7441
Echinococcus granulosus 7tm_1 domain containing protein 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus Protein kinase C brain isozyme 0.0034 0.0008 0.0027
Echinococcus granulosus neuropeptide FF receptor 2 0.0109 0.0931 0.3156
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis serotonin receptor 0.0109 0.0931 0.3156
Brugia malayi Egg laying defective protein 4 0.0044 0.0137 0.0129
Echinococcus granulosus tachykinin peptides receptor 99D 0.0109 0.0931 0.3156
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis serotonin receptor 0.0109 0.0931 0.3156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Brugia malayi Serotonin receptor 0.0109 0.0931 0.0924
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni biogenic amine receptor 0.0109 0.0931 0.3156
Onchocerca volvulus 0.0273 0.295 1
Echinococcus granulosus protein kinase C gamma type 0.0034 0.0008 0.0027
Brugia malayi Dopamine receptor protein 2 0.0109 0.0931 0.0924
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.0398 0.5
Echinococcus granulosus protein kinase c epsilon type 0.0034 0.0008 0.0027
Mycobacterium ulcerans hypothetical protein 0.0043 0.0118 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0931 0.3156
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0109 0.0931 0.3156
Echinococcus granulosus somatostatin receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0109 0.0931 0.3156
Brugia malayi neuropeptide F receptor 0.0109 0.0931 0.0924
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0034 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Entamoeba histolytica protein kinase, putative 0.0066 0.0398 0.0798
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Plasmodium falciparum cGMP-dependent protein kinase 0.0044 0.0137 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0109 0.0931 0.0924
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0298 0.7441
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0008 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi Protein kinase domain containing protein 0.0066 0.0398 0.039
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni neuropeptide receptor 0.0109 0.0931 0.3156
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0109 0.0931 0.3156
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0109 0.0931 0.0924
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0931 0.3156
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi Dopamine receptor 0.0109 0.0931 0.0924
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Schistosoma mansoni biogenic amine receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0931 0.3156
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi Dopamine receptor protein 1 0.0109 0.0931 0.0924
Echinococcus granulosus g protein coupled receptor 0.0109 0.0931 0.3156
Brugia malayi RE15519p 0.0109 0.0931 0.0924
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0008 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0109 0.0931 0.0924
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0931 0.3156
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0298 0.7441
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0931 0.0924
Schistosoma mansoni opsin-like receptor 0.0109 0.0931 0.3156
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0931 0.3156
Brugia malayi G protein-coupled receptor 0.0109 0.0931 0.0924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0008 0.0027
Echinococcus granulosus g protein coupled receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0109 0.0931 0.3156
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus cGMP dependent protein kinase 1 0.0044 0.0137 0.0464
Echinococcus granulosus allatostatin A receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0931 0.3156
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0008 0.0027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0109 0.0931 0.0924
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus rho-associated protein kinase 1 0.0273 0.295 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0066 0.0398 0.039
Schistosoma mansoni serine/threonine protein kinase 0.0273 0.295 1
Schistosoma mansoni amine GPCR 0.0109 0.0931 0.3156
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0109 0.0931 0.3156
Echinococcus multilocularis neuropeptide FF receptor 2 0.0109 0.0931 0.3156
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0109 0.0931 0.3156
Brugia malayi G-protein coupled receptor 0.0109 0.0931 0.0924
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Echinococcus granulosus G protein coupled receptor 139 0.0109 0.0931 0.3156
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0109 0.0931 0.3156
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0044 0.0137 0.0464
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0931 0.3156
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0137 0.0464
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924
Brugia malayi hypothetical protein 0.0109 0.0931 0.0924
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0109 0.0931 0.3156
Schistosoma mansoni neuropeptide f receptor 76f 0.0109 0.0931 0.3156
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0008 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.0109 0.0931 0.3156
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0931 0.0924

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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