Detailed information for compound 1407623

Basic information

Technical information
  • TDR Targets ID: 1407623
  • Name: 3-fluoro-N-[2-[1-(oxan-4-yl)piperidin-4-yl]py razol-3-yl]benzamide
  • MW: 372.437 | Formula: C20H25FN4O2
  • H donors: 1 H acceptors: 2 LogP: 2.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)C(=O)Nc1ccnn1C1CCN(CC1)C1CCOCC1
  • InChi: 1S/C20H25FN4O2/c21-16-3-1-2-15(14-16)20(26)23-19-4-9-22-25(19)18-5-10-24(11-6-18)17-7-12-27-13-8-17/h1-4,9,14,17-18H,5-8,10-13H2,(H,23,26)
  • InChiKey: WNANTONTAJOXED-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-fluoro-N-[2-(1-tetrahydropyran-4-yl-4-piperidyl)pyrazol-3-yl]benzamide
  • 3-fluoro-N-[2-[1-(4-tetrahydropyranyl)-4-piperidinyl]-3-pyrazolyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.4775 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.2319 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.2319 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.2319 0.2319
Loa Loa (eye worm) hypothetical protein 0.0025 0.2319 0.2319
Brugia malayi hypothetical protein 0.0025 0.2319 0.2319
Leishmania major hypothetical protein, conserved 0.0025 0.2319 0.2319
Leishmania major DNA polymerase eta, putative 0.0031 0.4775 0.4775
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.2319 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.2319 0.2319
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.2319 0.2319
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.4775 0.4775

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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