Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.2319 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.2319 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.2319 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.2319 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.4775 | 0.4775 |
Brugia malayi | hypothetical protein | 0.0025 | 0.2319 | 0.2319 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.4775 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.4775 | 0.4775 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.2319 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.2319 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.2319 | 0.2319 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.2319 | 0.2319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.