Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0028 | 0.3651 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.3651 | 0.645 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0285 | 0.0285 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.3651 | 0.3651 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0285 | 0.0285 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.3651 | 0.645 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.3651 | 1 |
Onchocerca volvulus | 0.0028 | 0.3651 | 0.5 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0285 | 0.0285 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.3651 | 0.3651 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5503 | 0.5503 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.3651 | 0.3651 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.3651 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5503 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3651 | 0.3651 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3507 | 0.3507 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0285 | 0.0285 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.3651 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.5503 | 0.5503 |
Schistosoma mansoni | lamin | 0.0028 | 0.3651 | 0.645 |
Echinococcus multilocularis | musashi | 0.0028 | 0.3651 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.3651 | 0.3651 |
Onchocerca volvulus | 0.0028 | 0.3651 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0028 | 0.3651 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50.9 uM | Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomes | ChEMBL. | No reference |
IC50 (binding) | = 50.9 uM | Compound was tested for its inhibitory activity against squalene epoxidase from rat liver microsomes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.