Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2037 | 0.6202 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0034 | 0.0934 | 0.2603 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0869 | 0.0869 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2037 | 0.6202 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0047 | 0.1627 | 0.1627 |
Echinococcus multilocularis | 0.0063 | 0.2425 | 0.2425 | |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0869 | 0.2505 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0018 | 0.0137 | 0.0428 |
Onchocerca volvulus | 0.0033 | 0.0869 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2037 | 0.2037 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0869 | 0.2714 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0089 | 0.0279 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0049 | 0.171 | 0.171 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0869 | 0.0869 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0049 | 0.171 | 0.521 |
Onchocerca volvulus | 0.0033 | 0.0869 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2037 | 0.2037 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0838 | 0.2618 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0047 | 0.1627 | 0.1627 |
Echinococcus multilocularis | Furin 1 | 0.0018 | 0.0137 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2037 | 0.2037 |
Echinococcus granulosus | Furin 1 | 0.0018 | 0.0137 | 0.0137 |
Schistosoma mansoni | lamin | 0.0033 | 0.0869 | 0.2388 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0049 | 0.171 | 0.171 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0869 | 0.2388 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0078 | 0.32 | 1 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0029 | 0.068 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.0869 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.32 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0047 | 0.1627 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0869 | 0.2505 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0047 | 0.1627 | 1 |
Brugia malayi | proprotein convertase 2 | 0.0049 | 0.171 | 0.521 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0869 | 0.2714 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0869 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0763 | 0.2384 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0869 | 0.0869 |
Schistosoma mansoni | lamin | 0.0033 | 0.0869 | 0.2388 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.021 | 1 | 1 |
Brugia malayi | celfurPC protein | 0.0063 | 0.2425 | 0.7507 |
Brugia malayi | endoprotease bli-4 precursor | 0.0078 | 0.32 | 1 |
Echinococcus granulosus | furin | 0.0078 | 0.32 | 0.32 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0078 | 0.32 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2037 | 0.6202 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0869 | 0.0869 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0869 | 0.0869 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2037 | 0.6261 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2037 | 0.2037 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2037 | 0.6365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3548 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.