Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AStacin protease | 0.032 | 0.4721 | 0.4721 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0512 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0458 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.9427 | 0.9427 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0165 | 0.0458 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0165 | 0.0458 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0165 | 0.0458 | 0.0458 |
Brugia malayi | Fibulin-1 precursor | 0.0165 | 0.0458 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0512 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0165 | 0.0458 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0149 | 0 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0512 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.