Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | transient receptor potential cation channel, subfamily C, member 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Echinococcus multilocularis | short transient receptor potential channel 6 | transient receptor potential cation channel, subfamily C, member 4 | 890 aa | 799 aa | 31.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.1868 | 0.5757 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2876 | 0.2457 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3245 | 0.2848 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0102 | 0.2715 | 0.7993 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.1868 | 0.5757 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0078 | 0.1893 | 0.5834 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0116 | 0.3189 | 0.275 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0086 | 0.2149 | 0.6622 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0116 | 0.3189 | 0.9827 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0691 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0606 | 0.0054 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0117 | 0.3245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3189 | 0.2789 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.1868 | 0.4782 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.1868 | 0.5757 |
Schistosoma mansoni | transient receptor potential channel | 0.0117 | 0.3245 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1267 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3189 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2876 | 0.2457 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0086 | 0.2149 | 0.6622 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 1 | 1 |
Brugia malayi | Transient-receptor-potential like protein | 0.0044 | 0.0691 | 0.009 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6661 | 0.5098 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.6661 | 0.5098 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1733 | 0.1247 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0082 | 0.2024 | 0.6238 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0116 | 0.3189 | 0.9787 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0044 | 0.0691 | 0.2128 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 1 | 1 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0116 | 0.3189 | 0.9827 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0116 | 0.3189 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1267 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1267 | 0.0754 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0116 | 0.3189 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.6279 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0113 | 0.311 | 0.9582 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0113 | 0.311 | 0.9582 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.1868 | 0.5757 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1267 | 0.0704 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0082 | 0.2024 | 0.6238 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0117 | 0.3245 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.1868 | 0.4782 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0116 | 0.3189 | 0.275 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0078 | 0.1893 | 0.5834 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0205 | 0.6279 | 0.4536 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0116 | 0.3189 | 0.5 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0044 | 0.0691 | 0.2128 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0117 | 0.3245 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 3.7573 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] | ChEMBL. | No reference |
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.