Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Giardia intestinalis | Putative fructose-1,6-bisphosphate aldolase | Starlite/ChEMBL | No references |
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 26.9 % |
Candida albicans | fructose-bisphosphate aldolase | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 358 aa | 22.6 % |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | Putative fructose-1,6-bisphosphate aldolase | 323 aa | 361 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0142 | 0.2792 | 0.3476 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.6209 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0172 | 0.354 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.254 | 0.254 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0044 | 0.0348 | 0.0561 |
Echinococcus granulosus | voltage gated potassium channel | 0.0044 | 0.0348 | 0.1145 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0152 | 0.3041 | 0.4898 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0044 | 0.0348 | 0.1145 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.6209 | 0.6209 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0152 | 0.3041 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0353 | 0.8032 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0142 | 0.2792 | 0.3476 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0432 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0432 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0348 | 0.0348 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0044 | 0.0348 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0152 | 0.3041 | 0.3041 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0172 | 0.354 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0166 | 0.3389 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0348 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0152 | 0.3041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0353 | 0.8032 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0044 | 0.0348 | 0.1145 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0172 | 0.354 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0348 | 0.1028 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0353 | 0.8032 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0166 | 0.3389 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.