Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9243 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.9243 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9243 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0131 | 0.007 | 0.2026 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9243 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0206 | 0.0152 | 0.4071 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0239 | 0.3989 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.0806 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3527 | 0.3771 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3527 | 0.3771 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3527 | 0.3771 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0181 | 0.0125 | 0.2085 |
Echinococcus granulosus | adam 17 protease | 0.0422 | 0.0387 | 0.6471 |
Onchocerca volvulus | 0.024 | 0.0189 | 0.3431 | |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0181 | 0.0125 | 0.2085 |
Echinococcus multilocularis | adam 17 protease | 0.0384 | 0.0345 | 0.5774 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3527 | 0.3771 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.015 | 0.4354 |
Treponema pallidum | polypeptide deformylase (def) | 0.9243 | 1 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0241 | 0.019 | 0.317 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0384 | 0.0345 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.0239 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0409 | 0.0373 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.015 | 0.4354 |
Echinococcus granulosus | geminin | 0.0205 | 0.015 | 0.2514 |
Schistosoma mansoni | hypothetical protein | 0.024 | 0.0189 | 0.547 |
Toxoplasma gondii | hypothetical protein | 0.9243 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0241 | 0.019 | 0.317 |
Onchocerca volvulus | Matrilysin homolog | 0.0375 | 0.0336 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0239 | 0.6389 |
Brugia malayi | Hemopexin family protein | 0.024 | 0.0189 | 0.5059 |
Plasmodium falciparum | peptide deformylase | 0.9243 | 1 | 0.5 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0181 | 0.0125 | 0.334 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0239 | 0.1826 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0152 | 0.0579 |
Loa Loa (eye worm) | matrixin family protein | 0.0409 | 0.0373 | 0.377 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0615 | 0.0598 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3527 | 0.3771 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0239 | 0.3989 |
Echinococcus multilocularis | geminin | 0.0205 | 0.015 | 0.2514 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3527 | 0.3771 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0375 | 0.0336 | 0.3238 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0375 | 0.0336 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.9243 | 1 | 1 |
Onchocerca volvulus | 0.0286 | 0.0239 | 0.5664 | |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0615 | 0.0598 | 1 |
Brugia malayi | Matrixin family protein | 0.0169 | 0.0112 | 0.2995 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0169 | 0.0112 | 0.3238 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.0201 | 0.539 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0181 | 0.0125 | 0.3612 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3527 | 0.3771 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.0201 | 0.1289 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8199 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.