Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0478 | 0.0772 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0478 | 0.0468 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0478 | 0.1044 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0031 | 0.0443 | 0.0694 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0165 | 0.458 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0021 | 0.0135 | 0.0295 |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0165 | 0.458 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0478 | 0.0772 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0165 | 0.458 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0031 | 0.0443 | 0.0968 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0118 | 0.3135 | 0.6845 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0021 | 0.0135 | 0.0125 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0031 | 0.0443 | 0.0968 |
Loa Loa (eye worm) | voltage-dependent calcium channel beta 2a subunit | 0.034 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0478 | 0.0772 |
Echinococcus granulosus | lamin | 0.0033 | 0.0478 | 0.0772 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0478 | 0.0468 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0478 | 0.0772 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0021 | 0.0135 | 0.0295 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.2606 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0135 | 0.0295 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0021 | 0.0135 | 0.0125 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0109 | 0.2827 | 0.2819 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0443 | 0.0433 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0109 | 0.2827 | 0.6056 |
Schistosoma mansoni | lamin | 0.0033 | 0.0478 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.046 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.2384 | 0.2376 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0031 | 0.0443 | 0.0433 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0031 | 0.0443 | 0.0694 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0118 | 0.3135 | 0.6845 |
Onchocerca volvulus | 0.0033 | 0.0478 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0031 | 0.0443 | 0.0694 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0021 | 0.0135 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0478 | 0.0468 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0021 | 0.0135 | 0.0295 |
Schistosoma mansoni | lamin | 0.0033 | 0.0478 | 0.1044 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.2606 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0478 | 0.0468 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0109 | 0.2827 | 0.2819 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0135 | 0.0125 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0109 | 0.2827 | 0.6056 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0478 | 0.0772 |
Onchocerca volvulus | 0.0033 | 0.0478 | 0.5 | |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0021 | 0.0135 | 0.0125 |
Echinococcus granulosus | voltage gated potassium channel | 0.0031 | 0.0443 | 0.0694 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0478 | 0.0468 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0021 | 0.0135 | 0.0295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.