Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.9707 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0136 | 0.5139 | 0.5294 |
Echinococcus granulosus | geminin | 0.0205 | 0.8793 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0.5139 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5554 | 0.5721 |
Onchocerca volvulus | 0.0136 | 0.5139 | 0.5294 | |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.5139 | 0.5294 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.9707 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5554 | 0.5721 |
Brugia malayi | Trypsin family protein | 0.0222 | 0.9707 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0136 | 0.5139 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0136 | 0.5139 | 0.5 |
Onchocerca volvulus | 0.0222 | 0.9707 | 1 | |
Brugia malayi | Kringle domain containing protein | 0.0136 | 0.5139 | 0.5294 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8793 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0222 | 0.9707 | 0.9398 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8793 | 0.7516 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8793 | 0.7516 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0136 | 0.5139 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5554 | 0.5721 |
Onchocerca volvulus | 0.0181 | 0.755 | 0.7778 | |
Brugia malayi | Protein kinase domain containing protein | 0.0136 | 0.5139 | 0.5294 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0136 | 0.5139 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6109 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.