Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Homo sapiens | integrin, alpha V | References | |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | integrin, alpha V | 1002 aa | 908 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.0369 | 0.6093 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0166 | 0.2112 | 0.4231 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.4351 | 0.9857 |
Echinococcus granulosus | integrin alpha 3 | 0.0283 | 0.4408 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0038 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0428 | 0.0428 |
Schistosoma mansoni | integrin alpha-ps | 0.0166 | 0.2112 | 0.2973 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.2858 | 0.2858 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0279 | 0.4335 | 0.6918 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0561 | 0.0561 |
Echinococcus granulosus | integrin alpha ps | 0.0166 | 0.2112 | 0.4231 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.4351 | 0.9857 |
Echinococcus multilocularis | integrin alpha ps | 0.0166 | 0.2112 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.4542 | 0.4542 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.4335 | 0.4335 |
Schistosoma mansoni | integrin alpha-ps | 0.0086 | 0.0561 | 0.0236 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.3229 | 0.4944 |
Echinococcus multilocularis | integrin alpha 3 | 0.0283 | 0.4408 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.6267 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0369 | 0.6093 | 0.9722 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0038 | 0.0061 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.6267 | 0.6267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.16 nM | Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3) | ChEMBL. | 15109653 |
IC50 (binding) | = 0.16 nM | Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3) | ChEMBL. | 15109653 |
IC50 (functional) | = 3 nM | Inhibition of human vascular smooth muscle proliferation was determined | ChEMBL. | 15109653 |
IC50 (functional) | = 3 nM | Inhibition of human vascular smooth muscle proliferation was determined | ChEMBL. | 15109653 |
IC50 (binding) | = 720 nM | Inhibitory activity was determined against human alpha IIb beta3 integrin | ChEMBL. | 15109653 |
IC50 (binding) | = 720 nM | Inhibitory activity was determined against human alpha IIb beta3 integrin | ChEMBL. | 15109653 |
Ratio (binding) | = 4500 | Ratio of inhibitory activity against human alpha V beta3 integrin to that of alpha IIb beta3 integrin | ChEMBL. | 15109653 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15109653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.