Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0235 | 0.2087 | 0.2118 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0674 | 0.0674 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.2087 | 0.2087 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0742 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0674 | 0.0674 |
Echinococcus granulosus | tar DNA binding protein | 0.0732 | 0.9851 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0235 | 0.2087 | 0.2087 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0732 | 0.9851 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0674 | 0.0674 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0153 | 0.0815 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0507 | 0.6337 | 0.6337 |
Brugia malayi | RNA binding protein | 0.0732 | 0.9851 | 0.9851 |
Schistosoma mansoni | tar DNA-binding protein | 0.0732 | 0.9851 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0235 | 0.2087 | 0.2087 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.2103 |
Schistosoma mansoni | hypothetical protein | 0.0235 | 0.2087 | 0.2118 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0732 | 0.9851 | 0.9851 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0234 | 0.2072 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2072 | 0.2072 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0153 | 0.0815 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0234 | 0.2072 | 1 |
Brugia malayi | TAR-binding protein | 0.0732 | 0.9851 | 0.9851 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0101 | 0 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.2103 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0235 | 0.2087 | 0.2087 |
Echinococcus granulosus | GPCR family 2 | 0.0235 | 0.2087 | 0.2118 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0742 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0235 | 0.2087 | 0.2118 |
Echinococcus multilocularis | GPCR, family 2 | 0.0235 | 0.2087 | 0.2118 |
Loa Loa (eye worm) | hypothetical protein | 0.0507 | 0.6337 | 0.6337 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0732 | 0.9851 | 0.9851 |
Loa Loa (eye worm) | TAR-binding protein | 0.0732 | 0.9851 | 0.9851 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0234 | 0.2072 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0234 | 0.2072 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0732 | 0.9851 | 0.9851 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0153 | 0.0815 | 0.0827 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0732 | 0.9851 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0153 | 0.0815 | 0.0827 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0235 | 0.2087 | 0.2118 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0235 | 0.2087 | 0.2118 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0235 | 0.2087 | 0.2118 |
Schistosoma mansoni | hypothetical protein | 0.0507 | 0.6337 | 0.6434 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0234 | 0.2072 | 0.2103 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0101 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0235 | 0.2087 | 0.2118 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0234 | 0.2072 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0732 | 0.9851 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0732 | 0.9851 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0732 | 0.9851 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0234 | 0.2072 | 0.2072 |
Schistosoma mansoni | hypothetical protein | 0.0235 | 0.2087 | 0.2118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.