Detailed information for compound 1422587

Basic information

Technical information
  • TDR Targets ID: 1422587
  • Name: N-(2-ethyl-6-methylphenyl)-2-[4-(3-methoxyphe nyl)-2,3-dioxopyrazin-1-yl]acetamide
  • MW: 393.436 | Formula: C22H23N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.99 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1ccn(c(=O)c1=O)CC(=O)Nc1c(C)cccc1CC
  • InChi: 1S/C22H23N3O4/c1-4-16-8-5-7-15(2)20(16)23-19(26)14-24-11-12-25(22(28)21(24)27)17-9-6-10-18(13-17)29-3/h5-13H,4,14H2,1-3H3,(H,23,26)
  • InChiKey: MGCPXAXGFASMAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-ethyl-6-methyl-phenyl)-2-[4-(3-methoxyphenyl)-2,3-dioxo-pyrazin-1-yl]acetamide
  • N-(2-ethyl-6-methylphenyl)-2-[4-(3-methoxyphenyl)-2,3-dioxo-1-pyrazinyl]acetamide
  • 2-[2,3-diketo-4-(3-methoxyphenyl)pyrazin-1-yl]-N-(2-ethyl-6-methyl-phenyl)acetamide
  • N-(2-ethyl-6-methyl-phenyl)-2-[4-(3-methoxyphenyl)-2,3-dioxo-pyrazin-1-yl]ethanamide
  • E209-1081
  • NCGC00121208-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.1779 1 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0253 0 0.5
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.1779 1 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3803 1
Onchocerca volvulus 0.1458 0.7894 0.5
Plasmodium falciparum ornithine aminotransferase 0.0253 0 0.5
Loa Loa (eye worm) pax transcription factor protein 2 0.1458 0.7894 0.5
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0253 0 0.5
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3803 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0253 0 0.5
Mycobacterium ulcerans hypothetical protein 0.1779 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3803 1
Brugia malayi Pax transcription factor protein 2 0.1458 0.7894 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.1779 1 1
Mycobacterium tuberculosis Probable aminotransferase 0.1779 1 1
Plasmodium vivax ornithine aminotransferase, putative 0.0253 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.