Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0236 | 0.689 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0236 | 0.689 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.5255 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0188 | 0.5255 | 0.7627 |
Brugia malayi | TAR-binding protein | 0.0188 | 0.5255 | 0.7627 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0549 | 0.0797 |
Brugia malayi | RNA binding protein | 0.0188 | 0.5255 | 0.7627 |
Onchocerca volvulus | 0.0048 | 0.0452 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0549 | 0.0797 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0549 | 0.0797 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.5255 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.5255 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.5255 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.5255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0549 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0452 | 0.0655 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0452 | 0.0859 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0188 | 0.5255 | 0.7627 |
Loa Loa (eye worm) | TAR-binding protein | 0.0188 | 0.5255 | 0.7627 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0188 | 0.5255 | 0.7627 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0236 | 0.689 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.