Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0092 | 0.2535 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0092 | 0.2535 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0092 | 0.2535 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0092 | 0.2535 | 1 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0092 | 0.2535 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0333 | 0.0333 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0328 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0333 | 0.0333 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0333 | 0.0333 |
Onchocerca volvulus | 0.0328 | 1 | 1 | |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0333 | 0.0333 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0328 | 1 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0328 | 1 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0092 | 0.2535 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0092 | 0.2535 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0092 | 0.2535 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0092 | 0.2535 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0092 | 0.2535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0092 | 0.2535 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0333 | 0.0333 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0333 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0092 | 0.2535 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0092 | 0.2535 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0333 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0333 | 0.0333 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0092 | 0.2535 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0333 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 9.4662 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.