Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative sulfate transporter | 0.0199 | 0.0701 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0948 | 0.4642 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1411 | 0.7079 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1762 | 0.8922 | 0.5 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.023 | 0.0863 | 0.1219 |
Toxoplasma gondii | hypothetical protein | 0.0813 | 0.3933 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1477 | 0.7423 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0069 | 0.0014 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1411 | 0.7079 | 0.9536 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1762 | 0.8922 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0813 | 0.3933 | 0.4399 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0069 | 0.0014 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1762 | 0.8922 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1762 | 0.8922 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1762 | 0.8922 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1762 | 0.8922 | 0.8223 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1762 | 0.8922 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1411 | 0.7079 | 0.6306 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.023 | 0.0863 | 0.1835 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1477 | 0.7423 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1762 | 0.8922 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1477 | 0.7423 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.1762 | 0.8922 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0813 | 0.3933 | 0.4399 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1411 | 0.7079 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1762 | 0.8922 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0813 | 0.3933 | 0.4399 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1762 | 0.8922 | 0.8223 |
Plasmodium falciparum | carbonic anhydrase | 0.0813 | 0.3933 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0883 | 0.4298 | 0.9256 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0759 | 0.3644 | 0.7843 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1762 | 0.8922 | 1 |
Onchocerca volvulus | 0.0199 | 0.0701 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 660 nM | Inhibition of nuclear factor of activated T-cells (NFAT) mediated transcription of beta-galactosidase in J.NFATZ.1 cells | ChEMBL. | 7629796 |
Ki (functional) | = 454 nM | Binding affinity of the compound was measured on jurkat cell membrane using [3H3C] as radioligand | ChEMBL. | 7629796 |
Ki (functional) | = 454 nM | Binding affinity of the compound was measured on jurkat cell membrane using [3H3C] as radioligand | ChEMBL. | 7629796 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7629796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.