Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Kringle domain containing protein | 0.0036 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.8328 | 0.7004 | |
Brugia malayi | SEA domain containing protein | 0.0025 | 0.4421 | 0.4421 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4421 | 0.4421 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.8328 | 0.8328 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.8328 | 0.7004 |
Onchocerca volvulus | 0.0036 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.8 | 0.8 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0036 | 1 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0025 | 0.4421 | 0.4421 |
Schistosoma mansoni | lamin | 0.0033 | 0.8328 | 0.7004 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0025 | 0.4421 | 0.4421 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.8328 | 0.8328 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.8328 | 0.8328 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.8328 | 0.8328 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.8328 | 0.8328 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0036 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.8328 | 0.7004 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4421 | 0.4421 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0036 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.8328 | 0.7004 | |
Leishmania major | hypothetical protein, conserved | 0.0036 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0036 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1778 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.