Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2366 | 0.9531 | 0.9112 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0069 | 0.0011 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2479 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0955 | 0.3681 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1421 | 0.5612 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0069 | 0.0011 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0889 | 0.3408 | 0.9256 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1487 | 0.5885 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2479 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0231 | 0.0684 | 0.1835 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1421 | 0.5612 | 0.9536 |
Plasmodium falciparum | carbonic anhydrase | 0.1206 | 0.4721 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.02 | 0.0555 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2479 | 1 | 1 |
Onchocerca volvulus | 0.02 | 0.0555 | 1 | |
Echinococcus granulosus | carbonic anhydrase | 0.1206 | 0.4721 | 0.4715 |
Echinococcus granulosus | carbonic anhydrase | 0.1206 | 0.4721 | 0.4715 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0763 | 0.2889 | 0.7843 |
Toxoplasma gondii | hypothetical protein | 0.1206 | 0.4721 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2479 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.2479 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1421 | 0.5612 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2479 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1206 | 0.4721 | 0.4715 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1487 | 0.5885 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.2479 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1487 | 0.5885 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0231 | 0.0684 | 0.1219 |
Schistosoma mansoni | carbonic anhydrase | 0.1421 | 0.5612 | 0.1689 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2479 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2479 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2479 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2479 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Inhibition of spontaneous tone in guinea pig tracheal spirals | ChEMBL. | 1875351 |
Intinsic activity (functional) | 0 | Intrinsic activity of the compound was evaluated by measuring inhibition of spontaneous tone in guinea pig tracheal spirals; ND = no data | ChEMBL. | 1875351 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.