Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ubiquitin specific protease, putative | ubiquitin specific peptidase 2 | 362 aa | 378 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0113 | 0.016 | 0.0429 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.04 | 0.1271 | 1 |
Brugia malayi | Presenilin family protein | 0.04 | 0.1271 | 0.1034 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.04 | 0.1271 | 0.3411 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.04 | 0.1271 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.04 | 0.1271 | 0.0834 |
Toxoplasma gondii | hypothetical protein | 0.014 | 0.0265 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1035 | 0.3727 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0376 | 0.1176 | 0.1176 |
Echinococcus multilocularis | Nicastrin | 0.0195 | 0.0477 | 0.0477 |
Brugia malayi | hypothetical protein | 0.0195 | 0.0477 | 0.0218 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2656 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2656 | 1 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0376 | 0.1176 | 0.0936 |
Echinococcus multilocularis | presenilin | 0.04 | 0.1271 | 0.1271 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1035 | 0.3727 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2656 | 1 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.04 | 0.1271 | 0.3411 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.04 | 0.1271 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2656 | 1 | 1 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.04 | 0.1271 | 0.3411 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.0477 | 0.0218 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.04 | 0.1271 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0376 | 0.1176 | 0.0936 |
Trypanosoma brucei | Aph-1 protein, putative | 0.1035 | 0.3727 | 1 |
Echinococcus granulosus | Nicastrin | 0.0195 | 0.0477 | 0.0477 |
Echinococcus granulosus | presenilin | 0.04 | 0.1271 | 0.1271 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.04 | 0.1271 | 1 |
Brugia malayi | hypothetical protein | 0.0195 | 0.0477 | 0.0218 |
Echinococcus multilocularis | Nicastrin | 0.0195 | 0.0477 | 0.0477 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0376 | 0.1176 | 0.1176 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.