Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0541 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0124 | 0.2255 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0135 | 0.1602 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0373 | 0.2608 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0124 | 0.2255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0135 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0373 | 0.2608 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0135 | 0.1602 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 0.0846 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0089 | 0.0498 | 0.5887 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0095 | 0.0541 | 0.0749 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0095 | 0.0541 | 0.6396 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0135 | 0.2504 |
Echinococcus granulosus | expressed conserved protein | 0.0089 | 0.0498 | 0.5887 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0373 | 0.2608 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0373 | 0.2608 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0373 | 0.2608 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0373 | 0.2608 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0095 | 0.0541 | 0.6396 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0135 | 0.1602 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0136 | 0.0846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0204 | 0.3772 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0095 | 0.0541 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0135 | 0.1602 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0124 | 0.2255 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0135 | 0.0188 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0135 | 0.2455 |
Brugia malayi | Telomerase reverse transcriptase | 0.0991 | 0.7222 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0552 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0124 | 0.2255 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0373 | 0.2608 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0179 | 0.2111 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0373 | 0.2608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0135 | 0.2504 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.