Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0321 | 0.099 | 0.0669 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0375 | 0.158 | 0.1189 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1095 | 0.9397 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0587 | 0.3881 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 0.158 | 0.1189 |
Leishmania major | carbonic anhydrase-like protein | 0.0587 | 0.3881 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0375 | 0.158 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0587 | 0.3881 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0347 | 0.1269 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0587 | 0.3881 | 0.3182 |
Trichomonas vaginalis | conserved hypothetical protein | 0.115 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0587 | 0.3881 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0587 | 0.3881 | 1 |
Onchocerca volvulus | 0.023 | 0 | 0.5 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0587 | 0.3881 | 0.3182 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0375 | 0.158 | 0.1189 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0291 | 0.0667 | 0.031 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0587 | 0.3881 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0587 | 0.3881 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.115 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0587 | 0.3881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1041 | 0.8812 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.023 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0587 | 0.3881 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0375 | 0.158 | 0.1189 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0587 | 0.3881 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0347 | 0.1269 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0375 | 0.158 | 0.1189 |
Plasmodium falciparum | carbonic anhydrase | 0.0375 | 0.158 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7305 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.