Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Woolly monkey sarcoma virus | Simian sarcoma virus Pol protein | Starlite/ChEMBL | References |
Mus musculus | polymerase (DNA directed), beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.0771 | 0.5 |
Echinococcus multilocularis | pol protein | 0.0259 | 0.6558 | 0.5 |
Echinococcus multilocularis | pol protein | 0.0259 | 0.6558 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.0771 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.372 | 0.3643 |
Echinococcus multilocularis | pol protein | 0.0259 | 0.6558 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus multilocularis | pol protein | 0.0259 | 0.6558 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4357 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4357 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0000032 M l-1 | Ability to inhibit simian sarcoma virus reverse transcriptase | ChEMBL. | 6154141 |
IC50 (binding) | = 0.000003200000000000001 M l-1 | Ability to inhibit simian sarcoma virus reverse transcriptase | ChEMBL. | 6154141 |
IC50 (binding) | = 0.0000074 M l-1 | Ability to inhibit mouse beta DNA polymerase | ChEMBL. | 6154141 |
IC50 (binding) | = 0.0000074 M l-1 | Ability to inhibit mouse beta DNA polymerase | ChEMBL. | 6154141 |
IC50 (binding) | = 0.000024 M l-1 | Ability to inhibit mouse alpha DNA polymerase | ChEMBL. | 6154141 |
Ki (binding) | = -0.97 | Ability to inhibit simian virus reverse transcriptase, expressed as log Ki. | ChEMBL. | 6154141 |
Log 1/C (binding) | = 5.13 | The logarithm of the reciprocal of the concentration which produces 50% inhibition of mammalian beta DNA polymerase. | ChEMBL. | 6154141 |
Log 1/C (binding) | = 5.49 | Inhibition of simian sarcoma virus reverse transcriptase | ChEMBL. | 6154141 |
Log 1/C (binding) | = 4.62 | The logarithm of the reciprocal of the concentration which produces 50% inhibition of mammalian alpha DNA polymerase. | ChEMBL. | 6154141 |
Log 1/C (binding) | = 5.13 | The logarithm of the reciprocal of the concentration which produces 50% inhibition of mammalian beta DNA polymerase. | ChEMBL. | 6154141 |
Log 1/C (binding) | = 5.49 | Inhibition of simian sarcoma virus reverse transcriptase | ChEMBL. | 6154141 |
Log Ki (binding) | = 0.97 | Ability to inhibit simian virus reverse transcriptase, expressed as log Ki. | ChEMBL. | 6154141 |
logP (ADMET) | = 3.6 | Partition coefficient (logP) | ChEMBL. | 6154141 |
logP (ADMET) | = 3.62 | Partition coefficient (logP) | ChEMBL. | 6154141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.