Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | GUP1, putative | 0.035 | 0 | 0.5 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.035 | 0 | 0.5 |
Trichomonas vaginalis | porcupine, putative | 0.035 | 0 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.035 | 0 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.035 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.035 | 0 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.035 | 0 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.035 | 0 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.035 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.035 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.035 | 0 | 0.5 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.035 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.035 | 0 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.3708 | 0.9057 | 0.9057 |
Loa Loa (eye worm) | MBOAT family protein | 0.4058 | 1 | 1 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.035 | 0 | 0.5 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.4058 | 1 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.4058 | 1 | 1 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.4058 | 1 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.035 | 0 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.3708 | 0.9057 | 0.9057 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.035 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.035 | 0 | 0.5 |
Onchocerca volvulus | 0.035 | 0 | 0.5 | |
Leishmania major | glycerol uptake protein, putative | 0.035 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.035 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.