Detailed information for compound 1436822

Basic information

Technical information
  • TDR Targets ID: 1436822
  • Name: 6-(5-chloro-2-methoxyphenyl)-N-ethyl-1,3,5-tr iazine-2,4-diamine
  • MW: 279.725 | Formula: C12H14ClN5O
  • H donors: 2 H acceptors: 3 LogP: 2.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc(N)nc(n1)c1cc(Cl)ccc1OC
  • InChi: 1S/C12H14ClN5O/c1-3-15-12-17-10(16-11(14)18-12)8-6-7(13)4-5-9(8)19-2/h4-6H,3H2,1-2H3,(H3,14,15,16,17,18)
  • InChiKey: DTPKYAHCQNHZKD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(5-chloro-2-methoxy-phenyl)-N-ethyl-1,3,5-triazine-2,4-diamine
  • [4-amino-6-(5-chloro-2-methoxy-phenyl)-s-triazin-2-yl]-ethyl-amine
  • ZINC00347264
  • Oprea1_790151
  • MLS000538218
  • N-[4-amino-6-(5-chloro-2-methoxyphenyl)-1,3,5-triazin-2-yl]-N-ethylamine
  • SMR000162788
  • AE-641/11703101

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldo-keto reductase 0.0215 0.3858 0.3858
Echinococcus granulosus aldo keto reductase 0.0215 0.3858 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase 0.0215 0.3858 1
Onchocerca volvulus 0.0215 0.3858 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0215 0.3858 1
Toxoplasma gondii aldose reductase, putative 0.0215 0.3858 1
Plasmodium falciparum aldo-keto reductase, putative 0.0215 0.3858 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0215 0.3858 0.5
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0215 0.3858 0.5
Toxoplasma gondii aldo-keto reductase 0.0215 0.3858 1
Onchocerca volvulus 0.0215 0.3858 1
Echinococcus granulosus hypothetical protein 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Trypanosoma cruzi aldo/keto reductase, putative 0.0215 0.3858 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Loa Loa (eye worm) oxidoreductase 0.0215 0.3858 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0215 0.3858 1
Leishmania major prostaglandin f synthase, putative 0.0215 0.3858 0.5
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0215 0.3858 0.5
Plasmodium falciparum aldehyde reductase, putative 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Mycobacterium ulcerans hypothetical protein 0.0215 0.3858 0.5
Schistosoma mansoni lipoxygenase 0.0087 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0215 0.3858 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0215 0.3858 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Onchocerca volvulus 0.0215 0.3858 1
Loa Loa (eye worm) oxidoreductase 0.0215 0.3858 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0215 0.3858 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0215 0.3858 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Leishmania major aldo-keto reductase-like protein 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Mycobacterium ulcerans oxidoreductase 0.0215 0.3858 0.5
Entamoeba histolytica aldose reductase, putative 0.0215 0.3858 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Schistosoma mansoni lipoxygenase 0.0124 0.2006 0.2006
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0215 0.3858 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Entamoeba histolytica aldose reductase, putative 0.0215 0.3858 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Giardia lamblia Aldose reductase 0.0215 0.3858 0.5
Trichomonas vaginalis aldo/keto reductase, putative 0.0215 0.3858 0.5
Echinococcus multilocularis voltage gated potassium channel subunit 0.0215 0.3858 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Schistosoma mansoni potassium channel beta 0.0215 0.3858 0.3858
Trichomonas vaginalis aldo/keto reductase, putative 0.0215 0.3858 0.5
Trypanosoma brucei aldo-keto reductase, putative 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus multilocularis aldo keto reductase 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0215 0.3858 0.5
Loa Loa (eye worm) oxidoreductase 0.0215 0.3858 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0215 0.3858 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0215 0.3858 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Mycobacterium tuberculosis Conserved protein 0.0215 0.3858 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.3858 0.5
Trypanosoma cruzi aldo/keto reductase, putative 0.0215 0.3858 0.5
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0118 0.1876 0.4863
Giardia lamblia Aldose reductase 0.0215 0.3858 0.5
Onchocerca volvulus 0.0215 0.3858 1
Onchocerca volvulus 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase 0.0215 0.3858 1
Onchocerca volvulus 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.2006 0.52
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase 0.0215 0.3858 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.2006 0.52
Schistosoma mansoni aldo-keto reductase 0.0215 0.3858 0.3858
Brugia malayi NADH-dependent xylose reductase 0.0215 0.3858 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0215 0.3858 1
Onchocerca volvulus 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Trypanosoma brucei aldo/keto reductase, putative 0.0215 0.3858 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0215 0.3858 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0215 0.3858 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0215 0.3858 1
Loa Loa (eye worm) oxidoreductase 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Schistosoma mansoni pol-related 0.0215 0.3858 0.3858
Schistosoma mansoni microsomal glutathione s-transferase 0.0118 0.1876 0.1876
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus granulosus microsomal glutathione S transferase 3 0.0118 0.1876 0.4863
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Loa Loa (eye worm) oxidoreductase 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase 0.0215 0.3858 1
Plasmodium vivax aldehyde reductase, putative 0.0215 0.3858 0.5
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0215 0.3858 1
Entamoeba histolytica aldose reductase, putative 0.0215 0.3858 0.5
Entamoeba histolytica alcohol dehydrogenase, putative 0.0215 0.3858 0.5
Trypanosoma brucei prostaglandin f synthase 0.0215 0.3858 0.5
Trypanosoma cruzi aldo-keto reductase 0.0215 0.3858 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0215 0.3858 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0215 0.3858 0.5
Mycobacterium leprae Possible oxidoreductase 0.0215 0.3858 0.5
Echinococcus granulosus aldo keto reductase 0.0215 0.3858 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0215 0.3858 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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