Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cysteine synthase a CysK1 | 0.0022 | 0.3773 | 0.5 |
Leishmania major | cysteine synthase | 0.0022 | 0.3773 | 0.5 |
Mycobacterium tuberculosis | Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) | 0.0022 | 0.3773 | 0.5 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0022 | 0.3773 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1026 | 0.1026 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0022 | 0.3773 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Mycobacterium tuberculosis | Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) | 0.0022 | 0.3773 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0022 | 0.3773 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0022 | 0.3773 | 0.5 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0022 | 0.3773 | 0.5 |
Leishmania major | cystathionine beta-synthase | 0.0022 | 0.3773 | 0.5 |
Brugia malayi | Pyridoxal-phosphate dependent enzyme family protein | 0.0022 | 0.3773 | 0.3061 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Entamoeba histolytica | cysteine synthase A, putative | 0.0022 | 0.3773 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Loa Loa (eye worm) | cbs-prov protein | 0.0022 | 0.3773 | 0.3773 |
Trichomonas vaginalis | threonine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Mycobacterium ulcerans | cysteine synthase B | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0022 | 0.3773 | 0.5 |
Toxoplasma gondii | CBS family protein | 0.0022 | 0.3773 | 0.5 |
Mycobacterium leprae | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) | 0.0022 | 0.3773 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Mycobacterium tuberculosis | Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0022 | 0.3773 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9646 | 0.9646 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trichomonas vaginalis | threonine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Brugia malayi | cbs-prov protein | 0.0022 | 0.3773 | 0.3061 |
Trypanosoma cruzi | cystathionine beta-synthase | 0.0022 | 0.3773 | 0.5 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trypanosoma cruzi | cystathionine beta-synthase, putative | 0.0022 | 0.3773 | 0.5 |
Mycobacterium ulcerans | cystathionine beta-synthase | 0.0022 | 0.3773 | 0.5 |
Toxoplasma gondii | pyridoxal-phosphate dependent superfamily protein | 0.0022 | 0.3773 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Trypanosoma cruzi | serine sulfhydrylase | 0.0022 | 0.3773 | 0.5 |
Trypanosoma brucei | cystathionine beta-synthase, putative | 0.0022 | 0.3773 | 0.5 |
Trichomonas vaginalis | cysteine synthase, putative | 0.0022 | 0.3773 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.