Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1294 | 0.1319 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.3319 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.3319 | 0.3385 |
Schistosoma mansoni | ryanodine receptor related | 0.0305 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.4883 | 0.485 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0161 | 0.4991 | 0.5057 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0161 | 0.4991 | 0.5057 |
Entamoeba histolytica | protein kinase, putative | 0.0114 | 0.3319 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.3319 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0299 | 0.9806 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0093 | 0.2607 | 0.2559 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0114 | 0.3319 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.2725 | 0.2725 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0114 | 0.3319 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.4991 | 0.4959 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.1977 | 0.1925 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0035 | 0.058 | 0.0519 |
Trypanosoma brucei | aurora B kinase | 0.0114 | 0.3319 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0161 | 0.4991 | 0.5057 |
Echinococcus multilocularis | insulin receptor | 0.0097 | 0.2725 | 0.2732 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0648 | 0.0661 |
Brugia malayi | cation channel family protein | 0.013 | 0.3904 | 0.3904 |
Loa Loa (eye worm) | ryanodine receptor | 0.0114 | 0.3329 | 0.3395 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.2725 | 0.2678 |
Loa Loa (eye worm) | MIR domain-containing protein | 0.002 | 0.0064 | 0.0065 |
Echinococcus granulosus | insulin receptor | 0.0097 | 0.2725 | 0.2732 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.3319 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0114 | 0.3319 | 0.3319 |
Brugia malayi | MIR domain containing protein | 0.002 | 0.0064 | 0.0064 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0037 | 0.0648 | 0.0588 |
Giardia lamblia | Aurora kinase | 0.0114 | 0.3319 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0247 | 0.7974 | 0.8119 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0097 | 0.2725 | 0.2732 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.4883 | 0.485 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0192 | 0.6077 | 0.6172 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0114 | 0.3319 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.3319 | 0.3385 |
Schistosoma mansoni | tyrosine kinase | 0.0161 | 0.4991 | 0.4959 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.2725 | 0.2678 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0299 | 0.9806 | 0.9806 |
Entamoeba histolytica | protein kinase , putative | 0.0114 | 0.3319 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0299 | 0.9806 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0114 | 0.3319 | 1 |
Toxoplasma gondii | aurora kinase | 0.0114 | 0.3319 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0114 | 0.3319 | 0.3341 |
Schistosoma mansoni | tyrosine kinase | 0.0299 | 0.9806 | 0.9805 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0114 | 0.3319 | 0.3341 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0247 | 0.7974 | 0.8119 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0114 | 0.3319 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0114 | 0.3319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.6077 | 0.6197 |
Loa Loa (eye worm) | ryanodine receptor | 0.0072 | 0.1864 | 0.1901 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0114 | 0.3319 | 0.3319 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0097 | 0.2725 | 0.2779 |
Onchocerca volvulus | 0.002 | 0.0064 | 0.5 | |
Echinococcus granulosus | aurora kinase A | 0.0114 | 0.3319 | 0.3341 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0114 | 0.3319 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1377 | 0.1405 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.3319 | 0.3276 |
Schistosoma mansoni | protein kinase | 0.0114 | 0.3319 | 0.3276 |
Schistosoma mansoni | tyrosine kinase | 0.0158 | 0.4883 | 0.485 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0299 | 0.9806 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0114 | 0.3319 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0114 | 0.3319 | 0.5 |
Echinococcus multilocularis | 0.0092 | 0.2572 | 0.2574 | |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0114 | 0.3319 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0114 | 0.3319 | 0.3319 |
Loa Loa (eye worm) | AUR protein kinase | 0.0114 | 0.3319 | 0.3385 |
Leishmania major | protein kinase, putative | 0.0114 | 0.3319 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0097 | 0.2725 | 0.2732 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0192 | 0.6077 | 0.6172 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.