Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0424 | 1 | 0.5 | |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.3158 | 0.3158 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0432 | 0.0432 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0432 | 0.0432 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0424 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3158 | 0.3158 |
Echinococcus multilocularis | protein will die slowly | 0.0424 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.073 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.073 | 0.073 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.073 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.3158 | 0.262 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3158 | 0.3158 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.073 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.3158 | 0.262 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.073 | 0.073 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.073 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.073 | 0.5 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0424 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.0424 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.073 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0424 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.3158 | 0.262 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.