Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.015 | 0.3756 | 0.6487 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0222 | 0.5791 | 0.5791 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.485 | 0.485 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0222 | 0.5791 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0369 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0369 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0222 | 0.5791 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0222 | 0.5791 | 0.5791 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0222 | 0.5791 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0222 | 0.5791 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0369 | 1 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.015 | 0.3756 | 0.6487 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.