Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0472 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.0472 | 1 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0425 | 0 | 0.5 |
Onchocerca volvulus | 0.0472 | 1 | 0.5 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0425 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0425 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0425 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0472 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0472 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.