Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | fatty-acid desaturase, putative | 0.1123 | 1 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.6572 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0888 | 0.7223 | 0.5 |
Onchocerca volvulus | 0.1123 | 1 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.6572 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.6572 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1123 | 1 | 0.5 |
Onchocerca volvulus | 0.1123 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0888 | 0.7223 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0888 | 0.7223 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0888 | 0.7223 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1123 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.