Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1506 | 1 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.1429 | 0.9431 | 0.5 |
Brugia malayi | valosin containing protein | 0.0883 | 0.5427 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.5059 | 0.2381 |
Loa Loa (eye worm) | VCP protein | 0.0623 | 0.3515 | 0.6476 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1506 | 1 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1429 | 0.9431 | 0.5 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0623 | 0.3515 | 0.6476 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1506 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0902 | 0.556 | 0.0000097958 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0883 | 0.5427 | 1 |
Mycobacterium ulcerans | ATPase | 0.0902 | 0.556 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1429 | 0.9431 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.5059 | 0.2381 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1429 | 0.9431 | 0.9122 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0902 | 0.556 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1429 | 0.9431 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1429 | 0.9431 | 0.5 |
Giardia lamblia | AAA family ATPase | 0.0902 | 0.556 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.5427 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1506 | 1 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1429 | 0.9431 | 0.5 |
Brugia malayi | vesicle-fusing ATPase | 0.0883 | 0.5427 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1506 | 1 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1429 | 0.9431 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (binding) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.