Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.01 | 0.0687 | 0.3844 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.2969 | 0.2969 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.019 | 0.1788 | 1 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.019 | 0.1788 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.019 | 0.1788 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.01 | 0.0687 | 0.3844 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.1875 | 0.7372 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.1875 | 0.7372 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.019 | 0.1788 | 0.703 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.9674 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.1875 | 0.1939 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.019 | 0.1788 | 0.1849 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.019 | 0.1788 | 1 |
Trypanosoma brucei | Enriched in surface-labeled proteome protein 12 | 0.01 | 0.0687 | 0.3844 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.01 | 0.0687 | 0.3844 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.154 | 0.1592 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.019 | 0.1788 | 1 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.019 | 0.1788 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.019 | 0.1788 | 0.1788 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.019 | 0.1788 | 0.1788 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.019 | 0.1788 | 0.1849 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.01 | 0.0687 | 0.3844 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.01 | 0.0687 | 0.3844 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.019 | 0.1788 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1875 | 0.1939 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2544 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.019 | 0.1788 | 0.1849 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.154 | 0.1592 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.019 | 0.1788 | 0.703 |
Onchocerca volvulus | 0.0286 | 0.2969 | 1 | |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.9674 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.019 | 0.1788 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1875 | 0.1939 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.019 | 0.1788 | 0.703 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.086 | 1 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.01 | 0.0687 | 0.3844 |
Trypanosoma brucei | hypothetical protein, conserved | 0.01 | 0.0687 | 0.3844 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2544 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.019 | 0.1788 | 0.703 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.9674 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.