Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0316 | 0.651 | 0.651 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0462 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0304 | 0.6225 | 0.6225 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0462 | 1 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0462 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Echinococcus granulosus | transcription factor Dp 1 | 0.0267 | 0.5351 | 0.5351 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0462 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0462 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0462 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0462 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0316 | 0.651 | 0.651 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0267 | 0.5351 | 0.5351 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0462 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.5603 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.