Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | No references | |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminase | 0.028 | 0.699 | 0.8481 |
Brugia malayi | glutaminase DH11.1 | 0.028 | 0.699 | 0.699 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2872 | 0.2872 |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 0.699 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0315 | 0.8068 | 0.8068 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.1005 | 0.1005 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.714 | 0.714 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0197 | 0.0197 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.374 | 0.3902 |
Mycobacterium ulcerans | glutaminase | 0.028 | 0.699 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.2767 | 0.2531 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.7004 | 0.8501 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0315 | 0.8068 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.8068 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.4084 | 0.4084 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.271 | 0.271 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.271 | 0.271 |
Echinococcus multilocularis | geminin | 0.0173 | 0.374 | 0.3902 |
Loa Loa (eye worm) | glutaminase 2 | 0.028 | 0.699 | 0.699 |
Loa Loa (eye worm) | glutaminase | 0.028 | 0.699 | 0.699 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.7004 | 0.8501 |
Echinococcus granulosus | geminin | 0.0173 | 0.374 | 0.3902 |
Echinococcus multilocularis | snurportin 1 | 0.0315 | 0.8068 | 1 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1554 | 0.1554 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.374 | 0.3902 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.4084 | 0.4387 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.2767 | 0.2531 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.5248 | 0.6026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | Biotinylated fibrinogen binding to alpha IIb beta3 integrin | ChEMBL. | No reference |
IC50 (binding) | > 1 uM | Biotinylated fibrinogen binding to alpha IIb beta3 integrin | ChEMBL. | No reference |
IC50 (functional) | = 9.8 uM | Inhibitory activity against ADP-mediated human platelet aggregation in human platelet rich plasma | ChEMBL. | No reference |
IC50 (functional) | = 9.8 uM | Inhibitory activity against ADP-mediated human platelet aggregation in human platelet rich plasma | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.