Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0096 | 0.0315 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.0987 | 0.323 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0987 | 0.323 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0118 | 0.0073 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0527 | 0.3055 | 0.5 |
Echinococcus granulosus | lamin | 0.0031 | 0.0096 | 0.0315 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0096 | 0.0315 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0527 | 0.3055 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0096 | 0.0315 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0527 | 0.3055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0987 | 0.323 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0118 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0093 | 0.0304 |
Trypanosoma brucei | squalene synthase, putative | 0.1691 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0096 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.3055 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0118 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.1691 | 1 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0527 | 0.3055 | 1 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0987 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0096 | 0.0885 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0118 | 0.0386 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.001 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0527 | 0.3055 | 1 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0527 | 0.3055 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0118 | 0.0386 |
Trypanosoma cruzi | squalene synthase, putative | 0.1691 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.0987 | 0.323 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0118 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0096 | 0.0315 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0096 | 0.0315 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0096 | 0.0885 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0096 | 0.0315 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0118 | 0.5 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0096 | 0.0315 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.0987 | 0.323 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0118 | 0.1106 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0118 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.