Detailed information for compound 1453428

Basic information

Technical information
  • TDR Targets ID: 1453428
  • Name: N-(3-fluoro-2-methylphenyl)-1,4-dimethyl-2-ox oquinoline-6-sulfonamide
  • MW: 360.403 | Formula: C18H17FN2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.42 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1C)NS(=O)(=O)c1ccc2c(c1)c(C)cc(=O)n2C
  • InChi: 1S/C18H17FN2O3S/c1-11-9-18(22)21(3)17-8-7-13(10-14(11)17)25(23,24)20-16-6-4-5-15(19)12(16)2/h4-10,20H,1-3H3
  • InChiKey: LPUIVDFKDCFWJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-fluoro-2-methyl-phenyl)-1,4-dimethyl-2-oxo-quinoline-6-sulfonamide
  • N-(3-fluoro-2-methylphenyl)-1,4-dimethyl-2-oxo-6-quinolinesulfonamide
  • N-(3-fluoro-2-methyl-phenyl)-2-keto-1,4-dimethyl-quinoline-6-sulfonamide
  • A3893/0165581
  • ZINC04742989

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0046 0.0019
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0027 0.0027
Echinococcus granulosus apoptotic protease activating factor 1 0.0123 0.2669 0.2669
Brugia malayi G-protein coupled receptor 0.0013 0.0046 0.0019
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0429 1 1
Brugia malayi ORL1-like opioid receptor 0.0013 0.0046 0.0019
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0046 0.0046
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0429 1 1
Onchocerca volvulus 0.0013 0.0046 0.0019
Onchocerca volvulus 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0429 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0027 0.0027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0359 0.0359
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0027 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0046 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0046 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0123 0.2669 0.2649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0046 0.0046
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0046 0.0046
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.015 0.3334 0.3315
Echinococcus granulosus sex peptide receptor 0.0013 0.0046 0.0046
Schistosoma mansoni amine GPCR 0.0013 0.0046 0.0046
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.015 0.3334 0.3315
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus serotonin receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0046 0.0019
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis caspase 2 0.0123 0.2669 0.2669
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0046 0.0046
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis apoptotic protease activating factor 1 0.0123 0.2669 0.2669
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0046 0.0046
Echinococcus granulosus gamma secretase subunit aph 1 0.0246 0.5622 0.5622
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0046 0.0046
Brugia malayi Serotonin receptor 0.0013 0.0046 0.0019
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0046 0.0019
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0046 0.0046
Brugia malayi Serotonin receptor 0.0013 0.0046 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0046 0.0019
Echinococcus granulosus g protein coupled receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0046 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0027 0.0027
Brugia malayi RE15519p 0.0013 0.0046 0.0019
Schistosoma mansoni biogenic amine receptor 0.0013 0.0046 0.0046
Echinococcus granulosus g protein coupled receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus hypothetical protein 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0027 0.0027
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0184 0.5
Echinococcus granulosus neuropeptide receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0123 0.2669 0.2649
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0046 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0027 0.0027
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0046 0.0046
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0184 0.5
Schistosoma mansoni opsin-like receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi Dopamine receptor protein 1 0.0013 0.0046 0.0019
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Schistosoma mansoni amine GPCR 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0027 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.2029 0.5
Brugia malayi G-protein coupled receptor 0.0013 0.0046 0.0019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0046 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Schistosoma mansoni bhlhzip transcription factor bigmax 0.015 0.3334 0.3334
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus neuropeptide receptor 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni hypothetical protein 0.0123 0.2669 0.2669
Onchocerca volvulus 0.0429 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0046 0.0046
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi larval opioid receptor 0.0013 0.0046 0.0019
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0027 0.0027
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0027 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0027 0.0027
Onchocerca volvulus 0.0013 0.0046 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0046 0.0046
Brugia malayi AKH receptor 0.0013 0.0046 0.0019
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0046 0.0046
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0046 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0046 0.0046
Schistosoma mansoni neuropeptide receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0046 0.0046
Brugia malayi gamma-secretase subunit aph-1 0.0246 0.5622 0.561
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0027 0.0027
Brugia malayi neuropeptide F receptor 0.0013 0.0046 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0027 0.0027
Schistosoma mansoni biogenic amine receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis inhibitor of apoptosis protein 0.0429 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0046 0.0046
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0046 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni amine GPCR 0.0013 0.0046 0.0046
Brugia malayi Melatonin receptor type 1A 0.0013 0.0046 0.0019
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0046 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0046 0.0046
Echinococcus granulosus caspase 2 0.0123 0.2669 0.2669
Brugia malayi Cell death protein 3 precursor 0.0123 0.2669 0.2649
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis somatostatin receptor 0.0013 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0027 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0046 0.0019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0046 0.0019
Echinococcus multilocularis serotonin receptor 0.0013 0.0046 0.0046
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0027 0.0027
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0046 0.0046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0027 0.0027
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0046 0.0046
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0046 0.0046
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0046 0.0019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0046 0.0019
Echinococcus granulosus fmrfamide receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis serotonin receptor 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.2669 0.2669
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0046 0.0046
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0046 0.0046
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0184 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Onchocerca volvulus 0.0013 0.0046 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Onchocerca volvulus Deterin homolog 0.0429 1 1
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0123 0.2669 0.2649
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0027 0.0027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0046 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni inhibitor of apoptosis protein 0.0429 1 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0184 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Echinococcus granulosus somatostatin receptor 0.0013 0.0046 0.0046
Schistosoma mansoni coup transcription factor 0.0012 0.0027 0.0027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi putative neuropeptide receptor 0.0013 0.0046 0.0019
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus max protein X 0.015 0.3334 0.3334
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0046 0.0019
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0046 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Brugia malayi Dopamine receptor 0.0013 0.0046 0.0019
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0046 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0027 0.0027
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0046 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0027 0.0027
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0359 0.0359
Brugia malayi G protein-coupled receptor 0.0013 0.0046 0.0019
Echinococcus multilocularis sex peptide receptor 0.0013 0.0046 0.0046
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0046 0.0046
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0046 0.0046
Brugia malayi Dopamine receptor protein 2 0.0013 0.0046 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0027 0.0027
Trypanosoma brucei Aph-1 protein, putative 0.0096 0.2029 0.5
Schistosoma mansoni bhlhzip transcription factor bigmax 0.015 0.3334 0.3334
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Schistosoma mansoni histamine h1 receptor 0.0013 0.0046 0.0046
Brugia malayi GnHR receptor homolog 0.0013 0.0046 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0013 0.0046 0.0019
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0359 0.0359
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0027 0.0027
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0013 0.0046 0.0019
Schistosoma mansoni neuropeptide receptor 0.0013 0.0046 0.0046
Schistosoma mansoni opsin-like receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni gamma-secretase subunit aph-1 0.0246 0.5622 0.5622
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0429 1 1
Schistosoma mansoni amine GPCR 0.0013 0.0046 0.0046
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0046 0.0019
Schistosoma mansoni neuropeptide receptor 0.0013 0.0046 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0046 0.0046
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0046 0.0046
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0246 0.5622 0.561
Echinococcus granulosus inhibitor of apoptosis protein 0.0429 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0027 0.0027
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0046 0.0019
Schistosoma mansoni amine GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni neuropeptide receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni hypothetical protein 0.0429 1 1
Schistosoma mansoni adenoreceptor 0.0013 0.0046 0.0046
Echinococcus granulosus g protein coupled receptor 0.0013 0.0046 0.0046
Echinococcus granulosus allatostatin A receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni opsin-like receptor 0.0013 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Onchocerca volvulus 0.0013 0.0046 0.0019
Onchocerca volvulus 0.0013 0.0046 0.0019
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0046 0.0019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0027 0.0027
Echinococcus multilocularis gamma secretase subunit aph 1 0.0246 0.5622 0.5622
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0046 0.0046
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0184 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Echinococcus multilocularis max protein X 0.015 0.3334 0.3334
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0046 0.0046
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni myosin xvIII 0.0013 0.0046 0.0046
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0046 0.0046
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0429 1 1
Schistosoma mansoni biogenic amine receptor 0.0013 0.0046 0.0046
Onchocerca volvulus Cell death protein 3 homolog 0.0123 0.2669 0.2649
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.0046 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Echinococcus granulosus orexin receptor type 2 0.0013 0.0046 0.0046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0046 0.0046
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.2029 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Brugia malayi sulfakinin receptor protein 0.0013 0.0046 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0027 0.0027
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0046 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0027 0.0027
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0046 0.0046
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0046 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0046 0.0046
Brugia malayi neuropeptide F receptor 0.0013 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0429 1 1
Onchocerca volvulus 0.0123 0.2669 0.2649
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0027 0.0027
Chlamydia trachomatis glutamine binding protein 0.0019 0.0184 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0027 0.0027
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0019
Onchocerca volvulus 0.0013 0.0046 0.0019

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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