Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.2073 | 0.3275 |
Echinococcus multilocularis | GPCR, family 2 | 0.0052 | 0.2073 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.2073 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.2073 | 0.3275 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.2073 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0113 | 0.6331 | 0.6331 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0052 | 0.2073 | 0.2073 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0052 | 0.2073 | 0.2073 |
Schistosoma mansoni | eyes absent homolog | 0.0099 | 0.5388 | 0.851 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0052 | 0.2073 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5388 | 0.5388 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.2073 | 0.3275 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2073 | 0.2073 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.6331 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.6331 | 0.6331 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0165 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0099 | 0.5388 | 0.5388 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.2073 | 0.3275 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0165 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0052 | 0.2073 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0052 | 0.2073 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0052 | 0.2073 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5388 | 0.5388 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0752 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.