Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0019 | 0.0019 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0019 | 0.0019 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0987 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.022 | 0.022 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.022 | 0.022 |
Leishmania major | stearic acid desaturase, putative | 0.0987 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0987 | 1 | 0.5 |
Onchocerca volvulus | 0.0987 | 1 | 0.5 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0987 | 1 | 0.5 |
Onchocerca volvulus | 0.0987 | 1 | 0.5 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0987 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0039 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0987 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.022 | 0.022 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0039 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0987 | 1 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0039 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.022 | 0.022 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0987 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0019 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0987 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0021 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.