Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.1642 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0586 | 0.2727 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0253 | 0.0431 | 0.0431 |
Echinococcus multilocularis | adam 17 protease | 0.0403 | 0.1466 | 0.1466 |
Leishmania major | hypothetical protein, conserved | 0.0257 | 0.0459 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0484 | 0.2026 | 0.2026 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0257 | 0.0459 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0443 | 0.1742 | 0.1742 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1642 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0098 | 0.0098 |
Giardia lamblia | Kinase, TTK | 0.0586 | 0.2727 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0098 | 0.0098 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.1642 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0098 | 0.0098 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0586 | 0.2727 | 1 |
Brugia malayi | Matrixin family protein | 0.0322 | 0.0908 | 0.0908 |
Echinococcus granulosus | geminin | 0.0205 | 0.0098 | 0.0098 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0586 | 0.2727 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0257 | 0.0459 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0586 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | TTK protein kinase | 0.0586 | 0.2727 | 0.2159 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0403 | 0.1466 | 0.1466 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.1642 | 1 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0586 | 0.2727 | 0.2727 |
Loa Loa (eye worm) | matrixin family protein | 0.0322 | 0.0908 | 0.0198 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0484 | 0.2026 | 0.2026 |
Loa Loa (eye worm) | hypothetical protein | 0.0847 | 0.4524 | 0.4096 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0586 | 0.2727 | 0.2727 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0257 | 0.0459 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0253 | 0.0431 | 0.0431 |
Brugia malayi | Protein kinase domain containing protein | 0.0586 | 0.2727 | 0.2727 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.1995 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.