TDR Targets

Basic information

Technical information

TDR Targets ID: 1460891
Name: 5-fluoro-2-methyl-1-[1-[(1-phenethyltetrazol- 5-yl)methyl]piperidin-4-yl]benzimidazole hydr ochloride
MW: 455.959 | Formula: C23H27ClFN7
H donors: 0 H acceptors: 4 LogP: 4.3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)nc(n2C1CCN(CC1)Cc1nnnn1CCc1ccccc1)C.Cl
InChi: 1S/C23H26FN7.ClH/c1-17-25-21-15-19(24)7-8-22(21)31(17)20-10-12-29(13-11-20)16-23-26-27-28-30(23)14-9-18-5-3-2-4-6-18;/h2-8,15,20H,9-14,16H2,1H3;1H
InChiKey: PJXYXBRLPHYRIW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-fluoro-2-methyl-1-[1-[(1-phenethyltetrazol-5-yl)methyl]-4-piperidyl]benzimidazole hydrochloride
5-fluoro-2-methyl-1-[1-[(1-phenethyl-5-tetrazolyl)methyl]-4-piperidinyl]benzimidazole hydrochloride
5-fluoro-2-methyl-1-[1-[(1-phenethyl-1,2,3,4-tetrazol-5-yl)methyl]piperidin-4-yl]benzimidazole hydrochloride
MLS000889498
5-Fluoro-2-methyl-1-[1-(1-phenethyl-1H-tetrazol-5-ylmethyl)-piperidin-4-yl]-1H-benzoimidazole
MLS000030165
SMR000006470

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	WNT	0.0272	0.4512	0.6259
Schistosoma mansoni	wnt related	0.0272	0.4512	0.6259
Schistosoma mansoni	wnt related	0.0272	0.4512	0.6259
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0	0.5
Echinococcus granulosus	secreted frizzled protein 5	0.0141	0.1907	0.2645
Echinococcus granulosus	frizzled	0.0141	0.1907	0.2645
Echinococcus multilocularis	wnt family member wnt11 2	0.0272	0.4512	0.6259
Echinococcus multilocularis	netrin 1	0.0408	0.7208	1
Echinococcus multilocularis	smoothened	0.0141	0.1907	0.2645
Echinococcus multilocularis	wingless type MMTV integration site family	0.0272	0.4512	0.6259
Echinococcus multilocularis	frizzled 10	0.0141	0.1907	0.2645
Loa Loa (eye worm)	hypothetical protein	0.0272	0.4512	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0272	0.4512	0.6259
Echinococcus multilocularis	protein Wnt 2	0.0272	0.4512	0.6259
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0141	0.1907	0.2645
Brugia malayi	wnt family protein	0.0272	0.4512	0.6259
Echinococcus multilocularis	secreted frizzled protein	0.0141	0.1907	0.2645
Brugia malayi	wnt family protein	0.0272	0.4512	0.6259
Loa Loa (eye worm)	wnt-4 protein	0.0272	0.4512	0.6259
Echinococcus granulosus	frizzled	0.0141	0.1907	0.2645
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0	0.5
Brugia malayi	Fz domain containing protein	0.0141	0.1907	0.2645
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.021	0.0291
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0	0.5
Echinococcus granulosus	protein Wnt 1	0.0272	0.4512	0.6259
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0	0.5
Schistosoma mansoni	wnt related	0.0272	0.4512	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1907	0.2645
Echinococcus multilocularis	frizzled 5	0.0141	0.1907	0.2645
Echinococcus granulosus	Protein Wnt-04	0.0272	0.4512	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0272	0.4512	0.6259
Echinococcus granulosus	protein Wnt 2	0.0272	0.4512	0.6259
Brugia malayi	Unc-6 protein precursor	0.0408	0.7208	1
Schistosoma mansoni	wnt inhibitor frzb2	0.0141	0.1907	0.2645
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.021	0.0291
Echinococcus multilocularis	frizzled	0.0141	0.1907	0.2645
Schistosoma mansoni	netrin	0.0408	0.7208	1
Brugia malayi	Wnt-4 protein precursor	0.0272	0.4512	0.6259
Schistosoma mansoni	netrin	0.0408	0.7208	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.021	0.0291
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0141	0.1907	0.2645
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0	0.5
Loa Loa (eye worm)	CWN-2 protein	0.0272	0.4512	0.6259
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0	0.5
Loa Loa (eye worm)	Wnt2 protein	0.0272	0.4512	0.6259
Schistosoma mansoni	wnt-5	0.0272	0.4512	0.6259
Schistosoma mansoni	frizzled-like receptor	0.0141	0.1907	0.2645
Schistosoma mansoni	wnt related	0.0272	0.4512	0.6259
Echinococcus granulosus	netrin 1	0.0408	0.7208	1
Echinococcus granulosus	frizzled 5	0.0141	0.1907	0.2645
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.021	0.0291
Schistosoma mansoni	frizzled-like receptor	0.0141	0.1907	0.2645
Loa Loa (eye worm)	frizzled/Smoothened family membrane region containing protein	0.0141	0.1907	0.2645
Echinococcus granulosus	Protein Wnt-11b	0.0272	0.4512	0.6259
Brugia malayi	Fz domain containing protein	0.0141	0.1907	0.2645
Schistosoma mansoni	frizzled	0.0141	0.1907	0.2645
Echinococcus granulosus	smoothened	0.0141	0.1907	0.2645
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.021	0.0291
Brugia malayi	wnt family protein	0.0272	0.4512	0.6259
Loa Loa (eye worm)	sfrp2	0.0141	0.1907	0.2645
Echinococcus multilocularis	WNT	0.0272	0.4512	0.6259
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0	0.5
Brugia malayi	Wnt-2 protein precursor	0.0272	0.4512	0.6259
Brugia malayi	Frizzled/Smoothened family membrane region containing protein	0.0141	0.1907	0.2645
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.021	0.0291
Schistosoma mansoni	secreted frizzled-related protein	0.0141	0.1907	0.2645
Echinococcus granulosus	frizzled 4	0.0141	0.1907	0.2645
Echinococcus granulosus	secreted frizzled protein	0.0141	0.1907	0.2645
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.021	0.0291
Echinococcus granulosus	Protein Wnt-5	0.0272	0.4512	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1907	0.2645
Loa Loa (eye worm)	hypothetical protein	0.0272	0.4512	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0408	0.7208	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0	0.5
Echinococcus multilocularis	frizzled	0.0141	0.1907	0.2645
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.021	0.0291
Brugia malayi	wnt family protein	0.0272	0.4512	0.6259
Echinococcus multilocularis	protein Wnt 1	0.0272	0.4512	0.6259
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.021	0.0291
Echinococcus multilocularis	secreted frizzled protein	0.0141	0.1907	0.2645
Echinococcus multilocularis	secreted frizzled protein 5	0.0141	0.1907	0.2645
Echinococcus granulosus	frizzled	0.0141	0.1907	0.2645
Echinococcus multilocularis	frizzled 4	0.0141	0.1907	0.2645
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0272	0.4512	0.6259
Echinococcus granulosus	Protein Wnt-111	0.0272	0.4512	0.6259

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.1995 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.929 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1361935

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1460891