Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.086 | 0.086 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0081 | 0.086 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0152 | 0.2688 | 0.2688 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0081 | 0.086 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0081 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin F homolog | 0.0081 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine protease, putative | 0.0081 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0081 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0059 | 0.0274 | 0.1018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0152 | 0.2688 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0081 | 0.086 | 1 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0081 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0081 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0059 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0081 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0081 | 0.086 | 0.086 |
Loa Loa (eye worm) | fibroinase | 0.0081 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0152 | 0.2688 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0081 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Echinococcus multilocularis | cysteine protease | 0.0081 | 0.086 | 0.086 |
Brugia malayi | cathepsin L-like precursor | 0.0059 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.0152 | 0.2688 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0152 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0081 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0081 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cysteine protease | 0.0081 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0059 | 0.0274 | 0.0274 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0081 | 0.086 | 0.086 |
Loa Loa (eye worm) | ctsf protein | 0.0081 | 0.086 | 0.0603 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0081 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0081 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin b | 0.0435 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0059 | 0.0274 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0081 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0152 | 0.2688 | 0.2482 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0081 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin b | 0.0435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0152 | 0.2688 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0152 | 0.2688 | 0.2688 |
Echinococcus multilocularis | cathepsin b | 0.0435 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0059 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0081 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0081 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0081 | 0.086 | 0.0603 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0435 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0435 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0435 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0152 | 0.2688 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0081 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin L homolog | 0.0081 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0081 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0152 | 0.2688 | 0.5 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.0274 | 0.0274 |
Brugia malayi | Cathepsin L-like precursor | 0.0081 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin l1 | 0.0081 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0081 | 0.086 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0059 | 0.0274 | 0.0274 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0081 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0435 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0059 | 0.0274 | 0.1018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0081 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0081 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0081 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0081 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.0274 | 0.0274 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.011 uM | Neuroprotective activity in human SH-SY5Y cells assessed as protection against 6-OHDA-induced cytotoxicity pretreated 1 hr before 6-OHDA challenge measured after 15 hrs by Alamar blue assay | ChEMBL. | 20980079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.