Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | high affinity choline transporter 1 | 0.0088 | 0.1999 | 0.1548 |
Brugia malayi | GH02984p | 0.0088 | 0.1999 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0989 | 0.0989 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0088 | 0.1999 | 0.1548 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1132 | 0.2886 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0533 | 0.0533 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0345 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0637 | 0.3187 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0345 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0345 | 1 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0088 | 0.1999 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0345 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.078 | 0.3903 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0345 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.1132 | 0.0633 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0088 | 0.1999 | 0.1548 |
Echinococcus granulosus | solute carrier family 5 | 0.0345 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0345 | 1 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0088 | 0.1999 | 0.1999 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1999 | 1 |
Schistosoma mansoni | inositol transporter | 0.0345 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.1132 | 0.0633 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0088 | 0.1999 | 0.5 |
Schistosoma mansoni | high-affinity choline transporter | 0.0088 | 0.1999 | 0.1999 |
Onchocerca volvulus | 0.0088 | 0.1999 | 0.5 | |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0088 | 0.1999 | 0.1548 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.1999 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Non-competitive inhibition of mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release at 0.1 uM to 1 uM by FLIPR assay | ChEMBL. | 21051228 | |
Activity (functional) | Agonist activity at mGluR5 in mouse astrocytes assessed as calcium release by FLIPR assay | ChEMBL. | 21051228 | |
IC50 (functional) | = 7.2 | Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilization | ChEMBL. | 21051228 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.