Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0047 | 0.0544 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0544 | 0.094 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0402 | 0.0678 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0156 | 0.9737 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0544 | 0.5 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 0.394 | 0.6803 |
Echinococcus multilocularis | protein patched | 0.0047 | 0.0544 | 0.0559 |
Onchocerca volvulus | 0.0087 | 0.394 | 1 | |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0047 | 0.0544 | 0.094 |
Echinococcus granulosus | expressed conserved protein | 0.0102 | 0.5234 | 0.5376 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0047 | 0.0544 | 0.0559 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0047 | 0.0544 | 0.0559 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0109 | 0.5792 | 0.5949 |
Echinococcus multilocularis | protein dispatched 1 | 0.0053 | 0.1102 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.5792 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0402 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1432 | 0.2472 |
Brugia malayi | CHE-14 protein | 0.0047 | 0.0544 | 0.094 |
Echinococcus multilocularis | expressed conserved protein | 0.0102 | 0.5234 | 0.5376 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0087 | 0.394 | 0.6803 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0402 | 0.0678 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0109 | 0.5792 | 0.5949 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.394 | 0.664 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0402 | 0.0678 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0109 | 0.5792 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0111 | 0.5934 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0109 | 0.5792 | 1 |
Schistosoma mansoni | patched 1 | 0.0047 | 0.0544 | 0.0917 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0156 | 0.9737 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 16 mm | Antifungal activity against Candida albicans at 100 ug/ml after 48 hrs by agar diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 18 mm | Antifungal activity against Candida albicans at 200 ug/ml after 48 hrs by agar diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 21 mm | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug/ml after 24 hrs by disc-diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 23 mm | Antibacterial activity against Escherichia coli ATCC 25922 at 200 ug/ml after 24 hrs by disc-diffusion method | ChEMBL. | 20965619 |
MBC (functional) | = 50 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs | ChEMBL. | 20965619 |
MFC (functional) | = 25 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs | ChEMBL. | 20965619 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth dilution technique | ChEMBL. | 20965619 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs | ChEMBL. | 20965619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.