Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0122 | 0.2682 | 0.2682 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.014 | 0.3204 | 0.2966 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0077 | 0.133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2682 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0145 | 0.3366 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0122 | 0.2682 | 0.2682 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0077 | 0.133 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0122 | 0.2682 | 0.1849 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0077 | 0.133 | 0.1027 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0077 | 0.133 | 0.133 |
Brugia malayi | WGR domain containing protein | 0.014 | 0.3204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2682 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0077 | 0.133 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0122 | 0.2682 | 0.2427 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.014 | 0.3204 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.014 | 0.3204 | 0.243 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.133 | 0.3232 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2211 | 0.764 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.014 | 0.3204 | 0.3204 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0077 | 0.133 | 0.0343 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0368 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.