Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase | References | |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | References | |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.1033 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.1033 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0247 | 0.1022 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.1033 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1234 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.1033 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1175 | 0.9459 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.1033 | 0.5 |
Onchocerca volvulus | 0.0247 | 0.1022 | 0.5 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.1033 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0344 | 0.1911 | 0.0669 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.1033 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.1033 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.1033 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.1033 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0285 | 0.137 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1234 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.1033 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.1033 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 28.5 nM | Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 63.7 nM | Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 376 nM | Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 2485 nM | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 2485 nM | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Ki (binding) | = 4760 nM | Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay | ChEMBL. | 21145236 |
Ki (binding) | = 5530 nM | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay | ChEMBL. | 21361354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.